Effect of lupeol isolated from Crataeva nurvala Buch.-Ham. stem bark extract against free radical induced nephrotoxicity in rats.
نویسندگان
چکیده
Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.
منابع مشابه
Chemical Examination and Biological Studies on the Bark of Crataeva nurvala Buch.-Ham
In continuation of our investigation on bioactive molecules, the melanin promotion activity-guided fractionation of the methanolic extract of the bark of Crataeva nurvala, yielded two known triterpenoid derivatives, lupeol (1) and lupenone (2). the structure of the compounds were established by physical and spectral data (UV, Ir, 1H, 13c nMr and Mass). the compounds were shown potent melanin pr...
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متن کاملScreening of antioxidant potential of selected barks of Indian medicinal plants by multiple in vitro assays.
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ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 42 7 شماره
صفحات -
تاریخ انتشار 2004